MATLAB is a multi-paradigm numerical computing environment and proprietary programming language developed by MathWorks. MATLAB allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages. MATLab is a powerful graphical calculator which is used to design calculator with a help of Graphical user interface GUI. Its built-in functions and libraries can be used for complicated calculations on large data sets. The results are visualized in the form of graphs and plots. Graphical user interface(GUI) Matlab was used to design a calculator which contains three things. The design working as division between two numbers, these two number can be any integer value. The system can also perform multiplication of two numbers and addition/subtraction. Design calculator with graphical user interface GUI can perform multi-task. The system capable of doing square roots and other mathematical problems.